AGE-RELATED VASCULAR EFFECTS OF PROSTAGLANDIN D2 (PGD2)
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چکیده
منابع مشابه
Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils.
Prostaglandin (PG) D2 acts through both the DP(1) receptor, which is coupled to adenylyl cyclase, and the DP2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells), which is present on eosinophils, basophils, and Th2 cells and results in cell activation and migration. The most potent prostanoid DP2 agonist so far reported is 15R-methyl-PGD2, in which the hydroxyl group ...
متن کاملHematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology
BACKGROUND The prostaglandin D2 (PGD2) pathway is involved in numerous biological processes and while it has been identified as a partner of the embryonic sex determining male cascade, the roles it plays in ovarian function remain largely unknown. PGD2 is secreted by two prostaglandin D synthases (Pgds); the male-specific lipocalin (L)-Pgds and the hematopoietic (H)-Pgds. METHODS To study the...
متن کاملPulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation.
Prostaglandin D2 (PGD2) can cause pulmonary vasoconstriction or vasodilation depending on animal species and age. Because the constrictor effects of PGD2 in some vascular beds may be mediated through thromboxane receptors, the purpose of this study was to determine whether the vascular or bronchial effects of PGD2 are mediated through thromboxane/endoperoxide (TX/E) receptor activation. In chro...
متن کاملTumor suppressor prostaglandin D2
Colorectal cancer is the cause of death for some 600,000 people per year in the world and patient numbers are still increasing. Risk of colorectal cancer is greatly increased by inherited factors, lifestyle (smoking or alcohol consumption) and microbial infections causing bowel inflammation (colitis). The prolongation of colitis leads to tumorigenesis. The mechanism by which chronic colitis dev...
متن کاملCentral cardiovascular and thermal effects of prostaglandin D2 in rats.
Prostaglandin D2 (PGD2) is the most common prostaglandin type of the rat brain. Recently a neuromodulator role for PGD2 has been suggested. In the present work the central cardiovascular and thermal effects of PGD2 were studied in urethane-anaesthetised rats. When administered at the doses of 0.001-10 micrograms/rat into the lateral cerebral ventricle (i.c.v.), PGD2 slightly increased the blood...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1984
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198404001-00418